The global chitosan derivatives market size was valued at US$ YY billion in 2020 and is estimated to reach US$ YY billion by 2028, growing at a CAGR of YY % during the forecast period (2021-2028).
Chitosan Derivatives, because of their capacity to penetrate GI barriers, induce mucoadhesion, and aid in transitory openings of tight junctions. Chitosan is a linear polysaccharide made up of N-acetyl-D-glucosamine and -linked D-glucosamine that are randomly dispersed.Its derivatives are extremely important in oral administration.
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Market Dynamics
The application of chitosan in biomedicine and the use of chitosan for oral insulin delivery is estimated to drive the market.
The application of chitosan in biomedicine is estimated to drive the market
Chitosan is made via the deacetylation of chitin, a naturally occurring protein. It has active functional groups that are susceptible to chemical reactions allowing for chitosan derivatives. Modification of chitosan has been a major focus of chitosan research, with results demonstrating improved solubility, pH-sensitive targeting and a greater number of delivery systems, among other things.
Antibacterial materials are a novel class of functional materials that have the capability of killing or suppressing germs. Antibacterial materials, such as antibacterial plastics, antibacterial fibres and fabrics, antibacterial ceramics, and antibacterial methicillin, are a type of new functional material that can inhibit or kill. Chitosan and chitosan derivatives have long been utilised as antibacterial agents that are non-toxic or low-toxic. Chitosan is one of them. For example, quaternized chitosan has dramatically improved antibacterial activity compared to chitosan and can be employed in anti-inflammatory medications or as a filler fibre in wound dressing materials.
Chitosan and quaternized chitosan have yet to be proven to have antibacterial properties. There are just three possibilities. (1) Because chitosan and chitosan derivatives are positively charged, and bacteria are negatively charged, they attract and interact with one another due to electrostatic adsorption; (2) after adsorbing bacteria, chitosan and chitosan derivatives enter the inside of bacterial cells and bind to DNA, interfering with bacterial DNA transcription, resulting in bacterial death. The other application of chitosan is in bone tissue engineering. In bone tissue engineering, Carboxymethyl chitosan is a regularly used material. CMCS can also be used to construct nanofiber scaffolds in addition to the applications shown in CMCS. For the development of periosteal mimics in BTE, TMC and heparinoid are routinely employed materials.
The use of chitosan for oral insulin delivery is estimated to drive the chitosan derivatives market in the forecast period
Diabetes mellitus is a chronic endocrine disorder that affects over 400 million people worldwide. Patients with poorly regulated blood glucose levels are at risk of developing life-threatening consequences including cardiovascular disease, neuropathy, retinopathy, and even death. Subcutaneous, parenteral insulin is still the most prevalent form of insulin therapy today. Patients find oral insulin treatment to be beneficial and convenient. Oral insulin administration, unlike injection, replicates the physiological process of endogenous insulin secretion. Due to the hostile physiological environment through the gastrointestinal track, oral insulin has a low absorption (less than 2%). (GIT). Using insulin encapsulation into nanoparticles as an advanced technique, several attempts have been undertaken over the last few decades to create an effective oral insulin formulation with high bioavailability. Nanoparticles as a delivery mechanism for oral insulin administration have been created using a variety of natural polymers.
Because of its appealing qualities, such as biodegradability, biocompatibility, bioactivity, nontoxicity, and polycationic nature, chitosan, a natural polymer, has been extensively investigated. Several researches have been undertaken to assess the capabilities of chitosan and chitosan derivatives-based nanoparticles for oral insulin administration. Nanocarriers can increase insulin absorption via the GI tract, transport insulin to the bloodstream, and lower blood glucose levels. Although significant flaws in the technology, chitosan and chitosan derivative-based nanoparticles are highly attractive candidates for oral insulin delivery. The U.S FDA has approved that chitosan is safe in the use of foods and drugs.
The challenges faced by chitosan derivatives are estimated to hamper the chitosan derivatives market
Because chitosan is insoluble in water and most organic solvents, its applicability scope and fields of use are severely limited. Only when chitosan is in the polycationic form and at pH values below the pKa does it have antibacterial properties. The electrostatic interactions between polycationic chitosan molecules and negatively charged cell envelopes are responsible for chitosan's antibacterial properties. If the positive charge of chitosan is neutralised, food components such as NaCl, proteins, and carbohydrates have a negative impact on its activity. In order to manufacture safe and effective chitosan products, a lot of research has been done recently. However, the poor stability of chitosan-based systems limits its practical application; hence, establishing an adequate shelf-life for chitosan formulations has become a major difficulty. Controlling environmental parameters, altering production settings (e.g., temperature), introducing a suitable stabilising component, producing chitosan blends with another polymer, or modifying the chitosan structure using chemical or ionic agents can all help to improve stability.
For instance, even though chitosan is a unique and adaptable chemical with a wide range of applications in the pharmaceutical and biomedical disciplines, there are few pharmaceutical products based on it (only hemostatic dressings, wound-healing preparations, and nutraceutical goods are available). This could be due to chitosan's high hygroscopicity and the fact that chitosan material isolated from different sources varies greatly in molecular weight and molecular weight distribution, degree of deacetylation, and purity level. Furthermore, chitosan's high vulnerability to external influences and processing conditions (such as heating or freezing) can cause structural stress and polymer degradation.
COVID-19 Impact Analysis
COVID-19 has affected the healthcare industry. To stop its development, government-imposed lockdown. Chitin and chitosan biopolymers, as well as their derivatives have been widely studied for their antibacterial characteristics. They have the ability to stop a wide spectrum of bacteria and fungus from growing. The antibacterial activities of chitin or chitosan as direct antimicrobial agents have been investigated against a variety of diseases. They exert antibacterial actions by interacting with the negative surfaces of bacterial membranes due to the presence of NH3+ groups. Some investigations have attempted to determine whether chitosan nanoparticle technology can prevent coronavirus infection. However, more research is needed to create a completely validated method based on the application of these nanoparticles and the specified polymers against COVID-19. Chitosan and its derivatives have a lot of potential for therapeutic use against COVID-19 soon. Hence, the chitosan derivatives market is estimated to see a positive impact in the forecast period.
Segment Analysis
By Derivative Type:
Carboxymethyl Chitosan
Chitosan HCl
Chitosan Quaternary Ammonium Salt
Hydroxypropyl Chitosan
By End-use:
Pharmaceutical and Bio-pharmaceutical
Biotechnology
Cosmetics
Other
Geographical Analysis
North America region is estimated to dominate the global chitosan derivatives market
More pharmaceutical and biopharmaceutical research and development in this region is estimated to dominate the chitosan derivatives market in this region.
The United States Food and Drug Administration (FDA) has approved that chitosan is safe in the use of foods and drugs. The American Society of Testing Materials (ASTM F04 division IV) is working to develop standards for tissue-created medical goods. The F2103 guidance explains how to evaluate chitosan salts for usage in medical applications. Furthermore, chitosan hydrochloride (a chitosan derivative) has been added to the European Pharmacopeia.
The biopharmaceutical industry in the United States stands out as leading research and development (R&D) and advanced manufacturing industry at a time when economic competitiveness at the national and state levels is recognised to be strongly rooted in the ability to advance innovation-based industries. Over the last 30 years, the United States has cemented its position as the world's leading biopharmaceutical innovator. Today, that global leadership is based on a strong foundation of U.S. enterprises that perform and support sophisticated R&D as well as maintain a broad and large-scale supply chain for biopharmaceutical research, production, and distribution. The United States is the world's largest biopharmaceutical market, accounting for almost a third of global sales, and the world's leader in biopharmaceutical research and development. According to the Pharmaceutical Research and Manufacturers Association (PhRMA), American companies do more than half of all pharmaceutical R&D ($75 billion) and own the intellectual property rights to the majority of new drugs.
Competitive Landscape
The major key players in the global chitosan derivatives market are FMC Corp, Kitozyme, Kunpoong Bio, BIO21, Heppe Medical Chitosan, Yaizu Suisankagaku, Golden-Shell, Lushen Bioengineering, AK BIOTECH, Zhejiang New Fuda Ocean Biotech, Weifang Sea Source Biological Products, Qingdao Honghai Biotech, Haidebei Marine Bioengineering, Jiangsu, Aoxin Biotechnology and Jinhu Crust Product.
FMC Corp
Overview: FMC Corporation is a global agricultural sciences firm dedicated to assisting growers in the production of food, feed, fibre and fuel for an ever-increasing global population while adapting to changing environmental conditions. Growers, crop advisers, turf and pest management specialists can more affordably address their most serious difficulties with FMC's revolutionary crop protection solutions, including biologicals, crop nutrition, digital, and precision agriculture.
capacity Product Portfolio: The company comprises of Crop Protection, Biologicals, Precision Agriculture, Plant Health, Agricultural Sciences, and Agriculture Chemicals
Key Development: In 2021, FMC Corporation formed a strategic partnership with UPL Ltd., a global provider of sustainable agriculture products and solutions, to extend Rynaxypyr active access to producers around the world and increase manufacturing.
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The Spirulina Market is expected to grow at a CAGR of 10.3% from 2020-2030, according to a new research report by Next Move Strategy ConsultingSpirulina is a blue green algae with high nutrient content, usually consumed by human & animals.
It is also used as a complementary diet ingredient in aquaculture & poultry feeds owing to the presence of high protein & vitamin content.According to the report, growth in health consciousness among people and the rising demand for dietary supplements are major factors driving the spirulina market growth.
Additionally, high penetration of spirulina in industries such as cosmetics and pharmaceutical owing to the advantageous properties such as anti-aging, anti-wrinkles and othersare bringing changes in market tends.However, low stability & poor sustainability of spirulina derived colours is expected to restrict the market growth.Moreover, growth in research & development activities followed by untapped market opportunities in developing economies are anticipated to provide numerous opportunities to the market players in the coming few years.On the basis of type, spirulina market share is segmented into Arthrospira Platensis and Arthrospira Maxima.
Arthrospira Maxima dominates the global Spirulina market and will be the dominant throughout the forecasted period.On the basis of application, the Spirulina market is categorised into Nutraceuticals, Food & Beverages, Cosmetics, Animal Feed, and Others.Food & Beverages segment is likely to develop significantly over the period of time owing to fast growing food & beverage industry.On the basis of drug formulation, the spirulina market is bifurcated into Powder, Tablet & Capsule, Liquid, and Granule & Gelling Agent.
Powder segment is expected to account for the major market share & dominate the market growth over the forecast period.North America dominates the spirulina market in terms of market size over the forecast period, owing to rising health consciousness among people.
Hansen Holding A/S, Algenol Biofuels Inc., Dongtai City Spirulina Bio-engineering Co., Ltd., Prolgae, Parry Neutraceuticals, Sensient Technologies Corporation, DDW Inc., Algatec and Naturex S.A.Browse key industry insights from the report, “Spirulina Market Size By Type (ArthrospiraPlatensis and Arthrospira Maxima) By Application (Nutraceuticals, Food & Beverages, Cosmetics, Animal Feed, and Others), By Drug Formulation (Powder, Tablet & Capsule, Liquid, and Granule & Gelling Agent)Regional Outlook (U.S., Canada, Germany, UK, France, Spain, Italy, Russia, China, India, Japan, Australia, Indonesia, Malaysia, South Korea, Brazil, Mexico, South Africa, Saudi Arabia, UAE, Kuwait), Growth Potential, Price Trends, Competitive Market Share & Forecast, 2020–2030” in detail along with the table of contents:Key Insights from the Spirulina Market Report:Asia Pacific is the fastest growing region in Spirulina market owing to the rising demand of spirulina from various industries such as cosmetics, food , healthcare and others and government initiatives to promote local spirulina production.The Food & Beverages segment dominates the market in terms of application and is expected to grow at a significant CAGR to maintain the lead till 2030.Some of the major players in the market are DIC Corporation, Cyanotech Corporation, Chr.
