Freedom of information requests by the i newspaper show that there have been 49 proximity reports by pilots since April 2014.
Pilots have called for better safety regulation to prevent a collision.
Drone users are advised to consult Civil Aviation Authority regulations and obtain permission from landowners before flying their devices.
But the figures show that in the first four months of 2016, there were 15 reported near-misses, more than half of total of 29 in the previous 12 months.
Steve Landells, flight safety specialist at the British Airline Pilots Association Balpa , said: Unless action is taken, Balpa believes the risk of collision is unacceptably high.
Drones fitted with cameras must not be flown within 50m 164ft of people, vehicles or buildings, or over congested areas or large gatherings such as concerts and sports events.