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Calvin Bourque 2021-07-13
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Here’s everything you need to know about The Suicide Squad on HBO Max, including its release date, cast, trailer, plot and more.
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Calvin Bourque 2021-04-29
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Men are to trial an at-home prostate cancer test.

Thousands of men will receive a letterbox-friendly home test kit to check for prostate cancer, which could help catch the disease years before other screening methods.

The simple urine test – dubbed the ‘Prostate Screening Box’ – is intended to diagnose aggressive prostate cancer without men having to leave their homes.

Currently, it’s hard to tell which types of prostate cancer can be left alone and which require urgent action. “It is not a simple matter to predict which tumours will become aggressive, making it hard to decide on treatment for many men,” says lead researcher Dr Jeremy Clark, from UEA’s Norwich Medical School.

But in a small pilot study, the new tests predicted which patients required treatment up to five years earlier than standard clinical methods.

Such tests are considered revolutionary because they could also mean men wouldn’t need to go to clinics for blood tests or rectal examinations in the future – and could instead be screened from the comfort of their own homes. 

How do the tests work?

The tests will be sent out as part of a trial run by the University of East Anglia and the Norfolk and Norwich University Hospital (NNUH). 

Men taking part in the trial will receive a home urine-sampling kit and will be asked to provide two urine samples – they’ll be asked to urinate into a test tube (via a funnel) first thing in the morning and then take another urine sample an hour later. The kit features funnels to help direct the flow of urination, two test tubes and their respective lids, and a timer.

The samples are then sent back to a lab for analysis. The test specifically looks at gene expression in urine samples and provides information about whether a cancer present is aggressive or ‘low risk’. Collected samples will be used to analyse the health of the prostate in 2,000 men in the UK, Europe and Canada.

“The Prostate Screening Box part sounds like quite a small innovation, but it means that in future the monitoring of cancer in men could be so much less stressful for them and reduce the number of expensive trips to the hospital,” says Dr Clark.

Why urine?

The prostate is a small gland in the pelvis found only in men. About the size of a walnut, it’s located between the penis and the bladder. It constantly produces secretions that naturally flow into the urethra – the tube through which urine passes from the bladder.

These secretions carry cells and molecules from all over the prostate which are flushed out of the body on urination. The test collects these and examines them. As Dr Clark explains: “It’s a way of sampling the whole prostate in one go.”

As the prostate is constantly secreting, the levels of biomarkers in the urethra will build up with time. Collecting from the first wee of the day means that overnight secretions can be collected which makes the analysis even more sensitive.

What does the trial hope to achieve?

The team has already trialled the kit in a small group of participants and are now rolling it out to thousands more men as part of the next phase in testing. Men can’t sign up for this particular phase of the trial as the charity Movember, which helped fund the research, has already identified those suitable to take part.

Samples will be collected from: men that have had a PSA test (a type of blood test used to screen for prostate cancer) and the result flags them up as possibly having prostate cancer; men with ‘low risk’ prostate cancer; and men with a genetic predisposition to having prostate cancer. These individuals will mostly be aged between 55 and 80 years old. 

Unsurprisingly, feedback so far has been positive. Participants from the early stage trials preferred the at-home test compared to having to go to hospital.

“We hope that using our Prostate Screening Box could in future revolutionise how those on ‘active surveillance’ are monitored for disease progression, with men only having to visit the clinic after a positive urine result,” says Dr Clark. “This is in contrast to the current situation where men are recalled to the clinic every six to 12 months for a range of tests.”

A negative urine test could enable men to only be retested every two to three years, relieving stress to the patient and reducing hospital workload, he adds.

Robert Mills, consultant clinical director in urology at NNUH, says the test has the potential to “significantly change” how prostate cancer is diagnosed and managed. If trials go well, the test could be landing on a doormat near you in three years’ time.

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Calvin Bourque 2021-02-12
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We pick a few games to enjoy with another, whether they're a newbie or hardcore.
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Calvin Bourque 2020-12-30
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McConnell introduced the bill after blocking a House version that would have boosted payments without tackling the two Trump agenda items.
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Calvin Bourque 2021-07-08
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The pandemic sparked a wave of home improvements but shrank the construction workforce, and now companies are scrambling to find labor.
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Calvin Bourque 2021-04-02
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The former House speaker was apparently drinking wine while recording, sources told Axios, and went off on Cruz while talking about freedom.
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Calvin Bourque 2021-02-01
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This month's focus is on reporter Mohamad Mosaed, an outspoken critic of the Iranian government's response to the Covid-19 pandemic.
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Calvin Bourque 2020-10-23
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"Cyberpunk 2077" is the next major game from the acclaimed game studio behind the "Witcher" franchise. Here's everything we know about it.
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Calvin Bourque 2021-06-19
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America's newest federal holiday marks the end of more than two centuries of slavery in the US.
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Calvin Bourque 2021-03-11
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The most popular songs to give birth to have been revealed – and Salt-N-Pepa’s Push It is shockingly absent.

Instead, mums-to-be seem to favour a chilled vibe, with Jack Johnson’s Better Together taking the top spot. The 2005 hit featured in more than half of the birth-related playlists analysed, with 460,197,498 plays on Spotify.

I Won’t Give Up by Jason Maraz came in second, featuring on 26 of the playlists with 530,386,616 plays overall. Meanwhile Make You Feel My Love by Adele took the third spot with 613,094,614 plays and appearing on 25 playlists.

Although he failed to make the top three, Ed Sheeran was the most popular birthing partner artist overall, with two of his songs making an appearance in the top 10. 

The researchers, working with Supplement Place, collated a list of 16,000 songs using playlists created by users that included the words “childbirth”, “birthing”, “birth”, “labour”, “birthing at home” and “hypnobirthing”. 

As well as looking at which songs and artists appeared most often, they looked at the average beats per minute (BPM) across all of the songs. 

The average BPM was 118, which is around the same speed as Alicia Keys, If I Ain’t Got You, Mae Robinson’s What a Wonderful World and Patricia by Florence and The Machine.

The research follows previous analysis, which identified Jeremih’s All The Time as the most popular track to have sex to, with Often by The Weeknd and Genuine’s Pony also making the top 10. 

Those lyrics have a lot to answer for. 

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Calvin Bourque 2021-01-23
img
MMA's biggest star steps back into the cage and our guide explains how to get a UFC 257 live stream - watch the McGregor vs Poirier 2 PPV tonight.
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0
Calvin Bourque 2020-08-28
img
Dr. Greg Reid interviewed billionaires and millionaires who shared money-making concepts that are so powerful, they'll challenge your imagination.
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0
Calvin Bourque 2021-06-10
img
Director Kate Herron talks about how the Disney Plus show redefines time travel in the Marvel Cinematic Universe.
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Calvin Bourque 2021-03-02
img
The European Space Agency wants to make sure its new astronaut class is more diverse. But it will take redesigned gear to make space accessible to everybody.
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0
Calvin Bourque 2021-01-12
img
The consumer tech show is virtual this year, and the WIRED Gear crew is watching all the Zooms to bring you up-to-the-minute highlights of news from CES.
collect
0
Calvin Bourque 2020-08-25
img
Bond set the standard for secret agents on screen, and the film franchise has stood the test of time. But don't jump in just anywhere.
collect
0
Calvin Bourque 2021-07-13
img
Here’s everything you need to know about The Suicide Squad on HBO Max, including its release date, cast, trailer, plot and more.
Calvin Bourque 2021-06-19
img
America's newest federal holiday marks the end of more than two centuries of slavery in the US.
Calvin Bourque 2021-04-29
img
Men are to trial an at-home prostate cancer test.

Thousands of men will receive a letterbox-friendly home test kit to check for prostate cancer, which could help catch the disease years before other screening methods.

The simple urine test – dubbed the ‘Prostate Screening Box’ – is intended to diagnose aggressive prostate cancer without men having to leave their homes.

Currently, it’s hard to tell which types of prostate cancer can be left alone and which require urgent action. “It is not a simple matter to predict which tumours will become aggressive, making it hard to decide on treatment for many men,” says lead researcher Dr Jeremy Clark, from UEA’s Norwich Medical School.

But in a small pilot study, the new tests predicted which patients required treatment up to five years earlier than standard clinical methods.

Such tests are considered revolutionary because they could also mean men wouldn’t need to go to clinics for blood tests or rectal examinations in the future – and could instead be screened from the comfort of their own homes. 

How do the tests work?

The tests will be sent out as part of a trial run by the University of East Anglia and the Norfolk and Norwich University Hospital (NNUH). 

Men taking part in the trial will receive a home urine-sampling kit and will be asked to provide two urine samples – they’ll be asked to urinate into a test tube (via a funnel) first thing in the morning and then take another urine sample an hour later. The kit features funnels to help direct the flow of urination, two test tubes and their respective lids, and a timer.

The samples are then sent back to a lab for analysis. The test specifically looks at gene expression in urine samples and provides information about whether a cancer present is aggressive or ‘low risk’. Collected samples will be used to analyse the health of the prostate in 2,000 men in the UK, Europe and Canada.

“The Prostate Screening Box part sounds like quite a small innovation, but it means that in future the monitoring of cancer in men could be so much less stressful for them and reduce the number of expensive trips to the hospital,” says Dr Clark.

Why urine?

The prostate is a small gland in the pelvis found only in men. About the size of a walnut, it’s located between the penis and the bladder. It constantly produces secretions that naturally flow into the urethra – the tube through which urine passes from the bladder.

These secretions carry cells and molecules from all over the prostate which are flushed out of the body on urination. The test collects these and examines them. As Dr Clark explains: “It’s a way of sampling the whole prostate in one go.”

As the prostate is constantly secreting, the levels of biomarkers in the urethra will build up with time. Collecting from the first wee of the day means that overnight secretions can be collected which makes the analysis even more sensitive.

What does the trial hope to achieve?

The team has already trialled the kit in a small group of participants and are now rolling it out to thousands more men as part of the next phase in testing. Men can’t sign up for this particular phase of the trial as the charity Movember, which helped fund the research, has already identified those suitable to take part.

Samples will be collected from: men that have had a PSA test (a type of blood test used to screen for prostate cancer) and the result flags them up as possibly having prostate cancer; men with ‘low risk’ prostate cancer; and men with a genetic predisposition to having prostate cancer. These individuals will mostly be aged between 55 and 80 years old. 

Unsurprisingly, feedback so far has been positive. Participants from the early stage trials preferred the at-home test compared to having to go to hospital.

“We hope that using our Prostate Screening Box could in future revolutionise how those on ‘active surveillance’ are monitored for disease progression, with men only having to visit the clinic after a positive urine result,” says Dr Clark. “This is in contrast to the current situation where men are recalled to the clinic every six to 12 months for a range of tests.”

A negative urine test could enable men to only be retested every two to three years, relieving stress to the patient and reducing hospital workload, he adds.

Robert Mills, consultant clinical director in urology at NNUH, says the test has the potential to “significantly change” how prostate cancer is diagnosed and managed. If trials go well, the test could be landing on a doormat near you in three years’ time.

Calvin Bourque 2021-03-11
img

The most popular songs to give birth to have been revealed – and Salt-N-Pepa’s Push It is shockingly absent.

Instead, mums-to-be seem to favour a chilled vibe, with Jack Johnson’s Better Together taking the top spot. The 2005 hit featured in more than half of the birth-related playlists analysed, with 460,197,498 plays on Spotify.

I Won’t Give Up by Jason Maraz came in second, featuring on 26 of the playlists with 530,386,616 plays overall. Meanwhile Make You Feel My Love by Adele took the third spot with 613,094,614 plays and appearing on 25 playlists.

Although he failed to make the top three, Ed Sheeran was the most popular birthing partner artist overall, with two of his songs making an appearance in the top 10. 

The researchers, working with Supplement Place, collated a list of 16,000 songs using playlists created by users that included the words “childbirth”, “birthing”, “birth”, “labour”, “birthing at home” and “hypnobirthing”. 

As well as looking at which songs and artists appeared most often, they looked at the average beats per minute (BPM) across all of the songs. 

The average BPM was 118, which is around the same speed as Alicia Keys, If I Ain’t Got You, Mae Robinson’s What a Wonderful World and Patricia by Florence and The Machine.

The research follows previous analysis, which identified Jeremih’s All The Time as the most popular track to have sex to, with Often by The Weeknd and Genuine’s Pony also making the top 10. 

Those lyrics have a lot to answer for. 

Calvin Bourque 2021-02-12
img
We pick a few games to enjoy with another, whether they're a newbie or hardcore.
Calvin Bourque 2021-01-23
img
MMA's biggest star steps back into the cage and our guide explains how to get a UFC 257 live stream - watch the McGregor vs Poirier 2 PPV tonight.
Calvin Bourque 2020-12-30
img
McConnell introduced the bill after blocking a House version that would have boosted payments without tackling the two Trump agenda items.
Calvin Bourque 2020-08-28
img
Dr. Greg Reid interviewed billionaires and millionaires who shared money-making concepts that are so powerful, they'll challenge your imagination.
Calvin Bourque 2021-07-08
img
The pandemic sparked a wave of home improvements but shrank the construction workforce, and now companies are scrambling to find labor.
Calvin Bourque 2021-06-10
img
Director Kate Herron talks about how the Disney Plus show redefines time travel in the Marvel Cinematic Universe.
Calvin Bourque 2021-04-02
img
The former House speaker was apparently drinking wine while recording, sources told Axios, and went off on Cruz while talking about freedom.
Calvin Bourque 2021-03-02
img
The European Space Agency wants to make sure its new astronaut class is more diverse. But it will take redesigned gear to make space accessible to everybody.
Calvin Bourque 2021-02-01
img
This month's focus is on reporter Mohamad Mosaed, an outspoken critic of the Iranian government's response to the Covid-19 pandemic.
Calvin Bourque 2021-01-12
img
The consumer tech show is virtual this year, and the WIRED Gear crew is watching all the Zooms to bring you up-to-the-minute highlights of news from CES.
Calvin Bourque 2020-10-23
img
"Cyberpunk 2077" is the next major game from the acclaimed game studio behind the "Witcher" franchise. Here's everything we know about it.
Calvin Bourque 2020-08-25
img
Bond set the standard for secret agents on screen, and the film franchise has stood the test of time. But don't jump in just anywhere.