What is Ledihep?
- Ledihep is an antiviral drug that prevents hepatitis C virus cells (HCV) from multiplying in your body.
- Ledihep is a combined drug used to treat hepatitis C in adults.
- Ledihep may also be used for purposes not listed in this medication guide.
Mechanism of action Ledihep drug
- Ledipasvir is a HCV inhibitor targeting the HCV NS5A protein, essential for both RNA replication and HCV virion assembly. It is currently not possible to confirm biochemical inhibition of NS5A by ledipasvir because NS5A has no enzyme function. In vitro and cross-resistance studies show that ledipasvir targets NS5A as its mode of action.
- Sofosbuvir is a pan genotype inhibitor of HCV NS5B-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide precursor that undergoes intracellular metabolism to form pharmacologically active triphosphate (GS-461203), which can be combined into HCV RNA by NS5B polymerase. GS-461203 (sofosbuvir's active metabolite) is neither a human DNA polymerase inhibitor nor a mitochondrial RNA polymerase inhibitor.
Ledihep contraindications:
- You are allergic to any of the ingredients in ledipasvir and sofosbuvir.
- You are taking another medicine that has sofosbuvir in it.
- You are taking a medicine that has cobicistat, elvitegravir, emtricitabine and tenofovir in it.
- You are taking carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, rosuvastatin, simeprevir, St. John's wort, or tipranavir / ritonavir Contact your doctor or doctor.
Drug interactions
- Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Ledihep, especially:
- Atripla (efavirenz, emtricitabine and tenofovir);
- Digoxin (digitalis);
- Other medicines to treat hepatitis C, such as simeprevir (Olysio) or Sofosbuvir (Ledihep) (Sovaldi);
- Ritonavir (Norvir) when used with tipranavir (Aptivus);
- Rosuvastatin (Badge);
- Tenofovir when used in combination with atazanavir, darunavir, lopinavir or ritonavir;
- Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir);
- Epilepsy drugs - carbamazepine, oxcarbazepine, phenobarbital, phenytoin;
- Stomach acid reducers - cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), ranitidine (Zantac), and others; or
- TB medicines - rifabutin, rifampin, rifapentine.
This list is not complete. Other drugs may interact with Ledihep, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Ledihep drug storage
- Store Ledihep at room temperature, 68 ° F to 77 ° F (20 ° C to 25 ° C).
- Keep the medication in the container it came in and hold the container tightly.
- Do not use Ledihep if the original seal on the container door is broken or missing.
- Throw away medications that are no longer needed or have expired (expired). Follow FDA guidelines on how to dispose of unused medicines safely.
- Keep medicines and all medicines out of the reach of children.
See more general knowledge information
- Thuoc ledihep dieu tri viem gan C – Gia thuoc ledihep https://nhathuocgan.com/thuoc-ledihep-dieu-tri-viem-gan-c/
- Thuoc Ledihep dong thuoc dac tri viem gan C hieu qua dieutriung https://dieutriung.org/thuoc-ledihep-tri-viem-gan-c/
- Thuoc Ledihep hoat chat Ledipasvir 90mg va Sofosbuvir 400 mg https://nhathuocgan.blogspot.com/2019/12/thuoc-ledihep-hoat-chat-ledipasvir-sofosbuvir.html
Description of the drug LedisofLedisof is a drug containing active ingredients Sofosbuvir 400mg and Ledipasvir 90mg used to treat hepatitis C genotypes 1a, 1b, 4,5,6 according to the MOH protocol.Ledisof is imported genuine from Hetero India and distributed into Vietnam market.Depending on the liver condition, Ledisof drug will be completely cured with 3 or 6 months of treatment.For patients with decompensated cirrhosis Ledisof in combination with Ribavin treatment from 3 to 6 months.Mechanism of actionLedisof is a fixed dose combination (FDC) of ledipasvir and sofosbuvir, which are antiviral drugs that act directly against hepatitis C virus (HCV).Ledipasvir is an inhibitor of the HCV NS5A protein, necessary for viral replication.
Sofosbuvir is an HCV NS5B-dependent RNA polymerase inhibitor, necessary for viral replication.Sofosbuvir is a nucleotide precursor that undergoes intracellular metabolism to form pharmacologically active uridine triphosphate (GS-461203), which can be combined with NS5B polymerase into RNA.Electrophysiology of the heartThorough research on QT has been conducted on ledipasvir and sofosbuvir.
The effect of ledipasvir 120 mg twice daily (2.67 times the maximum recommended dose); within 10 days for the QTc interval assessed at random; multiple doses, placebo and active control (moxifloxacin 400 mg); three times, throughout the QT Test in 59 healthy subjects.At a dose of 120 mg twice daily (2.67 times the maximum recommended dose), ledipasvir did not extend the QTc interval to any clinically appropriate level.
The effect of sofosbuvir 400 mg (maximum recommended dose) and 1,200 mg (triple the maximum recommended dose).For QTc intervals assessed in a randomized, single dose, placebo, and activity control (moxifloxacin 400 mg), four phases, cross-over meticulously tested in 59 healthy subjects.
At a dose three times the maximum recommended dose.How is this medicine Ledisof best taken?Use this medication as required by your doctor.
Follow all instructions closely.Take this medication at the same time of day.Bring with or without food.If you have trouble swallowing, talk to your doctor.Keep taking this medicine as you were told by your doctor or other health care provider, even if you feel fine.It is important that you do not miss or skip a dose of this medication during treatment.What do I do if I miss a dose?Miss a dose as soon as you think about it.If you do not think about the missed dose until the next day, skip the missed dose and return to your normal time.Do not exceed 1 dose of this medication on the same day.If you are not sure what to do if you miss a dose, call your doctor.Warning about drugs LedisofAlcohol: It is not known whether it is safe to use alcohol with Ledifos 90mg / 400mg Tablet.
Velpanat 400Mg tablet price in India, , we are leading suppliers and exporters of velpanat 400mg (Velpatasvir and Sofosbuvir) tablets in China, Russia, Hongkong, India.
The lowest price sellers, suppliers, distributors & Exporters from Delhi.
Online Velpanat 400Mg tablet suppliers in India
Velpanat tablet is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration which are direct-acting antiviral agents against the hepatits C virus.
the each tablet of it include the following inactive ingredients:copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.
Buy Online Suppliers price of Velpanat 400Mg India
The Global Sofosbuvir Market Report, in its latest update, highlights the significant impacts and the recent strategically changes under the present socio-economic scenario.
The Sofosbuvir industry growth avenues are deeply supported by exhaustive research by the top analysts of the industry.
The report starts with the executive summary, followed by a value chain and Marketing channels study.
The report then estimates the CAGR and Market revenue of the global and regional segments.Base Year: 2020Estimated Year: 2021Forecast Till: 2027The report classifies the market into different segments based on type and product.
These segments are studied in detail, incorporating the market estimates and forecasts at regional and country levels.
The segment analysis is helpful in understanding the growth areas and potential opportunities of the market.Get | Download FREE Sample Report of Global Sofosbuvir Market @ https://www.decisiondatabases.com/contact/download-sample-1967A special section is dedicated to the analysis of the impact of the COVID-19 pandemic on the growth of the Sofosbuvir market.
