
Radiotherapy of cancer has been a subject to get significant notice for clinical and research interest after the discovery of neutron. For instance, radiotherapy using fast neutron beam for the destruction of tumors cell is emerging as a promising technique on the basis of recent research data. Nowadays, neutron capture therapy (NCT) which is a somewhat different form of neutron-based therapy proposed by Locher in 1936 and particularly for intracranial tumors is proposed by Sweet in 1951.
In NCT, a neutron captured agent called yielding boron NCT has been guided into the malignant tissue, and after that, at a suitable time, the boron NCT is exposed by thermal neutrons generated by either an external neutron beam producer or a suitable nuclear-based accelerator. These thermal or high energetic neutrons interact with the boron NCT, which is actually present inside the malignant cells and generates highly energetic alpha particles and lithium ions within the cells which leads to their destruction by damaging its DNA itself.
Source: https://sgtuniversity.ac.in/blogs/use-of-physics-and-biophysics-in-cancer-treatment/