

Blood collection devices interact with blood, causing changes in blood composition, serum, and plasma fractions, as well as affecting laboratory testing in some situations. Vascular access devices can cause cells to lyse by releasing coating chemicals and exerting shear stresses. Additives in blood-dissolving tubes can impact the stability of blood constituents and analytical systems. Stoppers, lubricants, tube walls, surfactants, clot activators, and separator gels may be used to add materials, adsorb blood components, or interact with protein and cellular components. As a result, collection devices in laboratory testing can be a substantial source of preanalytical error.
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