A differential diagnosis for a physiologic pigmentation clinically in gums pigmented lesion. The gums procedure may include an array of traumatic, reactive, and neoplastic pathologies as well as gums hyperpigmentation associated with systemic disease. Lesions or conditions of physiologic pigmentation in melanocytic, vascular, hematopoietic, and hemosiderotic origin may be given consideration. physiologic pigmentation may also manifest as oral pigmentation is the prototypical example.
Where appropriate in physiologic pigmentation exogenous substances including chemical coloring agents in gingival pigmentation And amalgam, graphite, drug metabolites, and chromogenic bacteria could also be considered. To this end, the relatively common causes of physiologic pigmentation mucosal coloration, including petechiae, purpura, ecchymoses, hematomas, vascular tumors, and exogenous substances are not considered true in gums pigmented lesions. In physiologic pigmentation contrast, melanin is synthesized by gums lighteninig service.
It is true that the gums pigmentation usually imparts a brown, blue, or black gums physiologic pigmentation appearance to the mucosa.
Melanin ethnic pigmentation may be focal, multifocal, or diffuse depigmentation in its presentation. The physiologic pigmentation melanin is the gums pigmented derivative of tyrosine and is synthesized by melanocytes, which typically reside in the basal cell layer of the epithelium. In the gums pigmentstion melanin is thought to be cytoprotective against the damaging effects of sunlight.
The role of melanocytes in the physiologic pigmentation of oral epithelium remains unclear. Unless a patient is physiologic pigmentation of a race or ethnicity in which mucocutaneous gums pigmentation is physiologic, melanocytes are uncommonly observed in routine oral mucosal biopsies. Thus, in a Caucasian patient, oral melanocytic Multifocal pigmentation may not always be of any significant clinical consequence but it is always considered physiologic pigmentation in origin.
Pathologic melanin in physiologic pigmentation production within the oral mucosa may be associated with an array of etiologies of black gums and purple gums. The most concerning physiologic pigmentation in gums depigmented. These are malignant melanoma and various systemic disorders and including adrenal in physiologic pigmentation insufficiency and Cushing disease (discussed below). Importantly, the oral manifestations of these potentially gums Pinkened. Threatening disorders can diffuse pigmentation and mimic an array of physiologic pigmentation idiopathic, reactive, and benign neoplastic lesions. Thus, understanding the various disorders and substances that can contribute to physiologic pigmentation and oral mucosal coloration is essential for the appropriate evaluation, diagnosis, and management of the patient in physiologic pigmentation. This article focuses on oral pathologies of physiologic pigmentation melanocytic origin.
