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CAR T Cell Therapy: Pioneering A New Era In Oncology

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sachin sadgir
CAR T Cell Therapy: Pioneering A New Era In Oncology

The CAR is designed to recognize a specific antigen found on the surface of cancer cells. Once the CAR T cells are infused back into the patient's body, they seek out and bind to the cancer cells expressing the target antigen. This binding triggers the activation of the CAR T Cells Therepy leading to the destruction of the cancer cells through various mechanisms, including the release of cytotoxic molecules and the recruitment of other immune cells to the tumor site. These T cells are then genetically modified in the laboratory to express a chimeric antigen receptor (CAR) on their surface.


CAR T Cell Therapy has shown remarkable success in the treatment of certain types of blood cancers, particularly in patients who have not responded to or relapsed after other therapies. One of the most notable successes of CAR T cell therapy is seen in the treatment of acute lymphoblastic leukemia (ALL). Clinical trials have demonstrated high response rates, with a significant proportion of patients achieving complete remission. In fact, CAR T cell therapy has revolutionized the treatment landscape for pediatric and young adult patients with relapsed or refractory ALL.


The therapy begins by collecting T cells from the patient's blood through a process called leukapheresis. These T cells are then genetically engineered in a laboratory to express a chimeric antigen receptor (CAR) on their surface. The CAR is designed to recognize specific antigens present on the surface of cancer cells. Once the CAR T cells are produced, they are expanded in the laboratory and then infused back into the patient's bloodstream.

 

Once infused back into the patient's body, CAR T cells seek out cancer cells based on the specific antigen they are designed to recognize. When a CAR T cell encounters a cancer cell expressing the target antigen, it binds to the cancer cell and initiates a series of events leading to the destruction of the cancer cell.

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