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Ophthalmic Drugs: An Insight into Various Medications for Eye Care

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Leena Shedmake
Ophthalmic Drugs: An Insight into Various Medications for Eye Care

Antibiotics


Antibiotics are commonly prescribed to treat eye infections caused by bacteria. Some common antibiotics used for ophthalmic purposes include:


Tetracyclines such as doxycycline and minocycline work against a wide variety of bacteria including those that cause conjunctivitis (pink eye). They are usually prescribed as eye drops or ointments. These antibiotics are well-tolerated with minimal side effects.


Fluoroquinolones like ciprofloxacin and ofloxacin are broad-spectrum antibiotics effective against both gram-positive and gram-negative bacteria. They are prescribed for various bacterial eye infections like conjunctivitis, keratitis, and blepharitis. Topical fluoroquinolones are well-absorbed in the eye and reduce infection quickly with minimal adverse effects.


Aminoglycosides including gentamicin, tobramycin and amikacin help treat bacterial infections resistant to other classes of antibiotics. They are commonly used alongside another antibiotic for enhanced treatment of severe infections. Local side effects are rare with aminoglycoside eye drops but they should be used with caution in patients with renal impairment.


Anti-Inflammatory Drugs


Due to their anti-inflammatory properties, corticosteroids are often prescribed to reduce inflammation, swelling and discomfort associated with various eye conditions.


Corticosteroids like prednisolone, fluorometholone and loteprednol etabonate quickly relieve symptoms of redness, itching and irritation caused by conjunctivitis, uveitis, keratitis and post-surgery recovery. Topical corticosteroids are generally well-tolerated but may cause side effects with long-term use such as increased eye pressure and cataract formation.


Non-steroidal anti-inflammatory drugs (NSAIDs) including ketorolac, bromfenac and diclofenac work by blocking prostaglandin production. They are effective for symptomatic relief in conditions with ocular inflammation and pain like conjunctivitis, anterior uveitis, macular edema and post-surgical discomfort. NSAIDs typically have a better safety profile than corticosteroids with lower risks of glaucoma and cataracts.


Anti-Glaucoma Drugs


Glaucoma is a group of diseases characterized by increased pressure within the eye or optic nerve damage which can lead to vision loss if left untreated. Various medications are used to lower eye pressure in glaucoma:


Prostaglandin analogs like latanoprost, travoprost and bimatoprost work by increasing fluid outflow from the eye. Ophthalmic Drugs They are considered first-line treatment for glaucoma due to their high effectiveness and once-daily dosing with minimal side effects.


Beta blockers including timolol, levobunolol and betaxolol reduce fluid production inside the eye. They are well-tolerated but may cause breathlessness, bradycardia or hypoglycemia in susceptible individuals.


Carbonic anhydrase inhibitors such as dorzolamide and brinzolamide decrease fluid secretion. Topical administration results in few systemic side effects.


Alpha-adrenergic agonists like brimonidine protect the optic nerve by decreasing aqueous humor production. Common side effects include allergic conjunctivitis and dry mouth.


Combined medications containing both a beta blocker and carbonic anhydrase inhibitor in one drop offer enhanced IOP reduction with convenience of once-daily dosing.


Other Ophthalmic Drugs


In addition to antibiotics, anti-inflammatories and glaucoma medications, ophthalmologists may prescribe other types of eye drops or ointments to treat various ocular conditions:


Antihistamines - Oral as well as topical formulations of olopatadine, ketotifen and epinastine provide relief from allergic conjunctivitis symptoms.


Miotic agents - Pilocarpine is a parasympathomimetic miotic used to constrict the pupil and treat acute angle closure glaucoma by pulling the iris away from the trabecular meshwork.


Mydriatic agents - Atropine, homatropine and tropicamide are anticholinergic medications that dilate the pupil during eye exams by blocking the muscles that constrict the pupil.


Cycloplegic agents - Cyclopentolate and tropicamide are anticholinergic eyedrops that induce paralysis of the ciliary muscle resulting in dilation of the pupil and relaxation of accommodation during examination of the eye.


Artificial tears - Lubricating drops like hypromellose, carbomer, polyethylene glycol and glycerin are used to temporarily relieve dry, irritated or gritty eyes. Preservative-free varieties are recommended for frequent use.


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