What is Demineralized Bone Matrix?
Demineralized bone matrix (DBM) is an osteobiologic material that is derived from human or animal bones. It contains naturally occurring bone morphogenetic proteins (BMPs) and other growth factors that are essential for bone formation. DBM is created by removing mineral components from donated cadaver or animal bones through an acid extraction process, leaving behind a collagen matrix and protein growth factors. This process strips away the bone's minerals including calcium and retains the osteoinductive organic components that induce bone formation. Preparation and Characteristics of Demineralized Bone Matrix To prepare Demineralized Bone Matrix, bones from human or animal donors are treated with an acid solution to dissolve the mineral content and extract the collagen matrix. The extracted solution is then heat-treated and deorganized to preserve the biological activity of BMPs and other osteoinductive factors. The final processed DBM takes the form of a powder, gel, or putty that is easy to mix with bone voids or new bone graft. It maintains microscopic pore structure from the original bone to promote cellular infiltration and new bone ingrowth. DBM provides an osteoconductive scaffold as well as osteoinductive growth factors that recruit stem cells to the defect site and initiate the bone healing cascade. Clinical Applications of Demineralized Bone Matrix in Bone Repair DBM has been widely used in orthopedic and dental procedures as an alternative to autograft for bone repair and regeneration. Some common clinical applications include: - Spinal fusion surgeries - DBM is mixed with spinal bone graft extenders to promote fusion and healing of vertebrae. - Joint reconstruction - It can augment bone grafting in total hip and knee replacements to maximally fill defects and enhance bone bonding to implants. - Periodontal and dental procedures - Used as a graft material in jaw reconstruction and regrowth of alveolar bones supporting dental implants. - Foot and ankle reconstruction - Facilitates repair of navicular bone fractures, tibial and calcaneal osteotomies. - Non-union bone fractures - When mixed with bone marrow aspirate, DBM can stimulate healing of delayed-union or non-union fractures. Benefits and Effectiveness of Demineralized Bone Matrix The key advantages of DBM over autograft are its availability in unlimited supply, lack of donor site morbidity, and superior handling properties in surgery. Several clinical studies have demonstrated DBM to be as effective as autologous bone in stimulating new bone formation: - A meta-analysis of 30 randomized controlled trials found DBM grafts elicit similar bone regeneration compared to autografts in spinal fusion. - In foot and ankle surgery, DBM grafts achieved bony union rates of 85–95%, equivalent to autograft outcomes. - For oral and maxillofacial reconstruction, DBM showed 85–90% success in augmenting defect sites and promoting bone in-growth. - When combined with platelet-rich plasma, DBM stimulated significantly higher new bone formation than autograft alone in animal studies. Thus, DBM presents a safe and effective bone void filling alternative to autograft for various orthopedic procedures with reduced donor site problems. The osteoinductive properties of its endogenous growth factors enable comparable outcomes to the bone healing gold standard. Demineralized bone matrix is an osteoinductive bone graft material derived from human or animal bones through an acid extraction process. Retaining BMPs and other proteins essential for bone formation, DBM acts as both an osteoconductive scaffold and stimulant of new bone ingrowth. With unlimited supply and lack of donor morbidity, DBM has emerged as a viable option to autograft in promoting bone regeneration and repair in various orthopedic and dental clinical applications. Supported by abundant evidence from preclinical and clinical studies, DBM presents a highly effective graft substitute for enhanced bone healing.
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Moreover, this market report also covers regional and country markets in detail.The research report also covers the comprehensive profiles of the key players in the market and an in-depth view of the competitive landscape worldwide.
The major players in the demineralized bone matrix market include NovaBone Products, Zimmer Biomet, Exactech, Inc., AlloSource, LifeNet Health, Inc., Smith & Nephew., DePuy Synthes Companies, Medtronic plc, Wright Medical Group and Baxter International, Inc.
This section consists of a holistic view of the competitive landscape that includes various strategic developments such as key mergers & acquisitions, future capacities, partnerships, financial overviews, collaborations, new product developments, new product launches, and other developments.Get more information on "Global Demineralized Bone Matrix Market Research Report" by requesting FREE Sample Copy at https://www.valuemarketresearch.com/contact/demineralized-bone-matrix-market/download-sampleMarket DynamicsAn increase in the number of surgeries concerned to trauma and spinal issues has significantly increased the demand for a demineralized bone matrix.
Geriatric people are more susceptible to fractures, bone displacement, osteoporosis, etc., which require DBM.
Sales of the demineralized bone matrix are also expected to improve due to their use in dental implants to provide support.
However, the cost of demineralized bone matrix is significantly high, which makes it inaccessible to a majority of the population and might impact its sales.
Get FREE Sample Report Before Buying @ https://www.upmarketresearch.com/home/requested_sample/8627 UpMarketResearch offers a latest published report on “Global Demineralized Bone Matrix Market Analysis and Forecast 2018-2023” delivering key insights and providing a competitive advantage to clients through a detailed report.
Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report.
The numerical data is backed up by statistical tools such as SWOT analysis, BCG matrix, SCOT analysis, PESTLE analysis and so on.
The statistics are represented in graphical format for a clear understanding on facts and figures.
The generated report is firmly based on primary research, interviews with top executives, news sources and information insiders.
Region-wise Analysis Global Demineralized Bone Matrix Market covers:North AmericaEuropeChinaJapanIndiaSoutheast AsiaOther regions (Central & South America, Middle East & Africa) The Major players reported in the market include:NovaBoneZimmer BiometExactechAlloSourceLifeNet HealthSmith & NephewDePuy SynthesMedtronicWright MedicalBaxter For More Information, Please Visit https://www.upmarketresearch.com/home/enquiry_before_buying/8627 Global Demineralized Bone Matrix Market: Product Segment Analysis:AllograftAutograft Global Demineralized Bone Matrix Market: Application Segment Analysis:JointDental The Report covers in-depth analysis as follows:Chapter 1 Industry Overview of Demineralized Bone MatrixChapter 2 Manufacturing Cost Structure Analysis of Demineralized Bone MatrixChapter 3 Technical Data and Manufacturing Plants Analysis of Demineralized Bone MatrixChapter 4 Global Demineralized Bone Matrix Overall Market OverviewChapter 5 Demineralized Bone Matrix Regional Market AnalysisChapter 6 Global 2013-2018E Demineralized Bone Matrix Segment Market Analysis (by Type)Chapter 7 Global 2013-2018E Demineralized Bone Matrix Segment Market Analysis (by Application)Chapter 8 Major Manufacturers Analysis of Demineralized Bone MatrixChapter 9 Development Trend of Analysis of Demineralized Bone Matrix MarketChapter 10 Demineralized Bone Matrix Marketing Type AnalysisChapter 11 Consumers Analysis of Demineralized Bone MatrixChapter 12 Conclusion of the Global Demineralized Bone Matrix Market Professional Survey Report 2017 Buy Demineralized Bone Matrix Market analysis & forecast 2018-2023 Report along with complete TOC @ https://www.upmarketresearch.com/buy/demineralized-bone-matrix-market “Demineralized Bone Matrix Market Analysis and Forecast 2018-2023” report helps the clients to take business decisions and to understand strategies of major players in the industry.
