In a new study, researchers have found that an unknown family of viruses has become endemic in wild African primates and causes fatal Ebola-like symptoms in some monkeys, and is poised to infect humans. The findings were published online Sept. 30, 2022, in the journal Cell, in a paper titled "Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans".
Despite the fact that this virus family, known as arterivirus, has been identified as a major hazard to macaques, no human infections have been documented to yet. It is unknown what effect this virus might have on humans if it jumped species. However, by comparing them to simian immunodeficiency virus (SIV), a precursor virus to human immunodeficiency virus (HIV) that originated in African monkeys, these authors urge caution that by observing arteritis viruses in animals and humans today, the global health community may be able to avoid another pandemic.
Sara Sawyer, professor of molecular, cellular, and developmental biology at the University of Colorado at Boulder and co-corresponding author of the paper, stated, "Animal viruses have been known to enter human cells, multiply, and evade some important immune mechanisms that we would think would protect us from animal viruses. This is really unusual. We should be concerned about them."
There are thousands of different viruses circulating in animals all over the world, the vast majority of which do not cause any symptoms. In recent decades, a growing number of viruses have made their way to humans, wreaking havoc on immune systems that have never had to deal with them. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) in 2003, and SARS-CoV-2 (the coronavirus that causes COVID-19) in 2020 are among them.
For 15 years, Sawyer's lab has used laboratory techniques and tissue samples from wildlife around the globe to explore which animal viruses might be susceptible to infecting humans. She and the paper's lead author, Cody Warren, focused on arteritis viruses, which are abundant in pigs and horses but have received less attention in non-human primates (NHPs). They focused on simian hemorrhagic fever virus (SHFV), an ape arteritis virus that produces a lethal illness comparable to Ebola virus disease and was responsible for a devastating epidemic in captive macaque populations in the 1960s.
This new study indicates that a receptor protein known as CD163 is important in SHFV biology, helping it to penetrate and infect target cells. These researchers discovered, via a series of laboratory studies, that the virus is also quite proficient at attaching to the human form of CD163, entering human cells, and rapidly reproducing itself.
Simian arteritis virus, like HIV and its progenitor virus SIV, appears to assault immune cells, crippling important defensive mechanisms and replicating them in the body. "There are remarkable parallels between this virus and SIV, which created the HIV pandemic," Warren explained.
These authors underlined that another epidemic is not imminent and that the public should not be alarmed. They do, however, suggested that the global health community prioritize more studies on ape arteritis viruses, develop blood antibody testing against them, and investigate surveillance of human populations in close contact with animal carriers.
According to the report published by Allied Market Research, the global biotech ingredients market was pegged at $51.3 billion in 2020 and is estimated to hit $75.3 billion by 2028, registering a CAGR of 4.8% from 2021 to 2028.
The report provides an in-depth analysis of the top investment pockets, top winning strategies, drivers & opportunities, market size & estimations, competitive landscape, and changing market trends.Shift in consumer preference from synthetic to bio-based ingredients and development in biotechnology fuel the growth of the global biotech ingredients market.
On the other hand, limited availability of raw materials restrains the growth to some extent.
However, favorable government policies and technological advancements in bio-engineering are expected to create lucrative opportunities in the industry.Request PDF Brochure: https://www.alliedmarketresearch.com/request-sample/11710COVID-19 scenario-The outbreak of the pandemic has given way to either closure or suspension of production activities in most industrial units across the globe, which has impacted the market negatively.Nevertheless, initiation of mass vaccination in most countries is projected to mend the global situation and market is expected to get back on track soon.The global biotech ingredients market is analyzed across type, product, expression systems, and region.
The biosimilars segment, on the other hand, would exhibit the fastest CAGR of 5.0% during the forecast period.Based on product, the monoclonal antibodies segment contributed to more than one-fifth of the total market revenue in 2020 and is expected to dominate by 2028.
However, the hormones and growth factors segment would cite the fastest CAGR of 5.5% during from 2021 to 2028.Get Detailed COVID-19 Impact Analysis on the Biotech Ingredients Market: https://www.alliedmarketresearch.com/request-for-customization/11710?reqfor=covidBased on region, Europe held the major share in 2020, garnering nearly two-fifths of the global market.
