Another sniffle, another sneeze. You cannot wait to get your hands on some nasal spray to get rid of your blocked nose as quickly as possible. According to the best nasal spray device supplier, correct positioning and procedure are the keys to achieving the best results.
Acute and chronic drug treatments for various neurodegenerative and psychiatric disorders are difficult. These are listed below.
- Oral drugs' low bioavailability and small reaction with the brain,
- Rapid metabolism and elimination,
- Unwanted side effects,
- The high dose causes inconvenience for the patients and their families.
- High costs for the patients, their families, and society.
There is a reason for the compounds' low brain penetration. It occurs due to those having to resolve the 'blood-brain barrier,' which safeguards the brain from xenobiotics. One of the promising approaches to bypassing the blood-brain barrier is intranasal drug administration.
Nasal spray pumps lessen the drugs' systemic side effects and the doses that must be managed. Furthermore, drugs administered via the nasal route typically have higher bioavailability, fewer side effects, and higher brain interaction at a comparable dosage than oral drugs.
Challenges for the development of nasal sprays:
Ø Intranasal drug administration has grown in popularity since the 1980s. The nasal pathway is a non-invasive route for administering active pharmaceutical ingredients for local, institutional, and CNS action. Although the nasal epithelium would seem to be a tight hindrance, the intercellular junctional complex of the nasal mucosa has a low stiffness due to leaky epithelial tissue.
Ø The molecules are absorbed directly into the brain through the trigeminal and olfactory channels from the nasal cavity. It produces a favorable pharmacokinetic or pharmacodynamic profile for CNS-acting drugs.
Moreover, this encouraging alternative approach to enteral and systemic drug administration is highly potent and efficacious for dosing. Avoiding the major physiological barriers can reach the brain parenchyma.
Various nasal drug delivery models:
Many serious brain-related diseases still are challenges for researchers and, obviously, for doctors. Therefore, nasal drug delivery models can detect and test nasal drug absorption and permeation. It is also used to evaluate drug transporter interactions and nasal barriers.
The in vivo, in vitro, and ex vivo models are frequently used in nose drug delivery experimental tests. The various models can be used for a variety of studies.
What is the purpose of nasal sprays?
Nasal sprays target inflammation in your nasal cavity, which diminishes swelling and helps clear up your stuffy nose. Several nasal sprays are designed to heal allergy symptoms and can be utilized long-term. Decongestant nasal sprays, a third type, should only be used for a few days and are best for treating congestion affected by a cold or the flu.
Efficiently handle the ‘Rebound Effect’:
Have you ever learned that if you use a nasal spray too frequently, you will no longer benefit from it? The rebound effect is what it's called, and it's only feasible with one type of nasal spray, and it's the only one you shouldn't use for more than a few days in a row.
There are several types of nasal sprays, and it's critical to understand what you're using, how frequently you should use it, and whether it's habit-forming. Only nasal decongestant sprays can cause a ‘rebound effect.’ Thus, people should consult their physician and take the prescribed doses of their nasal sprays.
Aptar offers the best modern solution of nasal sprays and powder. As we are the best nasal spray device supplier, we spend significant time researching.
