The global phosphoramidite market comprises of several nucleoside and amino acid derivatives that acts a building blocks in nucleic acid modification & DNA/RNA synthesis. Phosphoramidites are used as reagents for oligonucleotide synthesis using solid-phase synthesis techniques. Phosphoramidites have a very good leaving group property and reacts with alcohol/acid in a nucleophilic substitution reaction during solid-phase DNA synthesis. Key advantages of using phosphoramidites are that they carry protective groups to avoid unfavorable side reaction during solid-phase synthesis and they produce phosphodiester bonds with high yields. The increasing application of DNA/RNA synthesis in the fields of precision medicine, molecular diagnostics, genomics and pharmacogenomics is driving the demand for phosphoramidites.
The Global Phosphoramidite Market is estimated to be valued at US$ 1,011.3 MN in 2024 and is expected to exhibit a CAGR of 7.3% over the forecast period 2024 to 2031.
Key Takeaways
Key players operating in the global phosphoramidite market include Glen Research, ChemGenes Corporation, Link Technologies Ltd., BioAutomation Corporation, Merck KGaA, Sigma-Aldrich (now part of MilliporeSigma, a Merck Group company), LGC Biosearch Technologies, Thermo Fisher Scientific, Biosynthesis Inc., ATDBio Ltd., Genscript Biotech Corporation, Expedeon AG, Wuxi Donglin Sci & Tech Development Co., Ltd., Bio-Synthesis Inc., and ChemGenes Corporation.
Phosphoramidite Market Demand is increasing from biotechnology and pharmaceutical industries where DNA/RNA synthesis is integral part of research. Precision medicine and molecular diagnostics are two major application areas fueling the market growth.
Latest technological advancements like automated DNA synthesis systems, advancements in protecting groups chemistry are helping industry players to develop improved and high purity phosphoramidite building blocks.
Market Trends
Two major trends prevailing in the global phosphoramidite market include growing adoption of synthetic biology applications and advancements in oligonucleotide therapeutics development. Synthetic biology applications like gene & genome engineering requires modified oligos which drives the demand. Also, oligonucleotide therapeutics like antisense, siRNA and aptamers have potential to treat various diseases and this offers new opportunities.
Market Opportunities
Untapped markets in emerging countries and development of personalized medicine provides key growth opportunities. Healthcare sector growth in developing countries will augment the phosphoramidite consumption. Also, with advancements in areas of CRISPR, further innovations can be expected requiring modified phosphoramidite building blocks.
Impact of COVID-19 on the Global Phosphoramidite Market
The COVID-19 pandemic has significantly impacted the growth of the global phosphoramidite market. During the beginning of the pandemic, several restrictions were imposed by various governments which disrupted the supply chain networks and halted manufacturing operations. This led to a decline in the demand and supply of phosphoramidites as the end-use industries like biotechnology and pharmaceutical reduced their operations.
However, with the resumption of manufacturing activities and relaxation in lockdown measures, the market is gradually recovering. There is an increased focus on research related to vaccines and drugs for COVID-19 which is driving the demand for phosphoramidites as they are widely used in DNA/RNA synthesis. Various market players are also investing in production capacity expansion to cater to this rising demand. Government funding for COVID-19 related research is further expected to support market growth.
While short term impact was negative, the pandemic emphasized the importance of pharmaceutical and biotechnology industries. In the long run, increased focus on drug development and investment in healthcare infrastructure will create lucrative opportunities for phosphoramidite market. Key market players need to focus on strengthening supply chain and ensure smooth supply to fulfil the rising demand from research laboratories. Geographic expansion into high growth emerging markets would also help to sustain post pandemic growth trajectory.
Geographical Regions with High Concentration in the Global Phosphoramidite Market
North America dominates the global phosphoramidite market in terms of value. The region accounts for over 35% share attributed to well-established pharmaceutical and biotechnology industries in countries like the US and Canada. Presence of leading market players and availability of advanced research infrastructure supports the regional market growth.
Asia Pacific is considered as the fastest growing region for phosphoramidite market driven by countries like China, India, Japan and South Korea. Factors such as rising government investments in healthcare sector, growing biotechnology industry and increasing outsourcing of clinical research to Asia Pacific countries are fueling the demand. Additionally, increasing awareness about applications of phosphoramidites in drug discovery and therapeutics would drive the APAC market during the forecast period.
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