Pain, especially chronic pain, is a significant burden all over the world. Millions of people today are suffering from chronic pain. And because of this, the quality of their lives and daily activities is greatly affected.
No doubt, medications such as opioids are effective in treating pain. But they also come with a dark side. Using opioids can lead to addiction, constipation, and other health issues.
That’s the reason you must avoid using opioids for treatment if you have chronic pain.
But if opioids are not the correct medicine for chronic pain treatment, then which would be another one? Are you wondering about it?
If yes, then this article is for you!
Here, you will learn about the Conolidine alkaloid. It is a natural alkaloid known for its pain-suppressing potential.
Are you interested in learning about this pain-killing alkaloid? Then, continue reading!
Conolidine as an Analgesic Alkaloid
Conolidine is an alkaloid that falls under the class of indole alkaloids. Indole alkaloids have many chemicals, but only Conolidine is unique as it has pain-killing properties.
This pain-killing alkaloid is found in the Tabernaemontana divaricata plant. This tropical flowering shrub is also called the crepe jasmine plant. It is traditionally used for fever and pain relief.
If we talk about Conolidine’s mode of action, it works like an opioid but does not cause side effects like them. That’s why it is considered as a non-opioid analgesic.
How the Pain-Relieving Effects of Conolidine Differs from Opioids
After understanding how Conolidine has come into the limelight, it’s time to learn how Conolidine works differently than Opioids.
Opioids directly target pain receptors. But Conolidine works through a unique mechanism.
Our bodies create natural painkillers known as endorphins. However, a receptor called ACKR3 can act like a sponge that absorbs the natural painkillers before they can fulfill their job of relieving pain.
That’s where Conoldine alkaloid shows its magic.
It interacts with ACKR3 and impedes its ability to absorb endorphins. This may facilitate the free flow of endorphins and their binding to appropriate receptors. Therefore, it enhances the body’s endogenous pain-relieving capacities.
Safety and Efficacy of Non-Opioid Analgesic in Pain Treatment
Conolidine is a safer analgesic than opioids. This is because opioids cause severe side effects such as constipation, respiratory depression, addiction, reliance, and brain fog.
However, the non-opioid pain reliever works in a unique mode of action and has natural ingredients. So it is safe to use.
In terms of efficacy, this non-opioid analgesic treats different kinds of pain, especially chronic pain, which is challenging to treat with opioids.
Promising Developments in Pain Relief
CONOCB2, the pain relief product of Conolidine, has been launched recently. It is a dietary supplement available in oral and topical form.
Conolidine CONOCB2 is a daily-use supplement that is sustainable and safe for treating various medical disorders. According to clinical tests, you feel relieved and relaxed within 3 to 5 days.
Current Phase of Research on Conolidine
While Conolidine CONOCB2 has emerged as a promising new analgesic drug in the treatment of chronic pain, more research is needed to clarify its medication interactions or various biological targets.
Conclusion
That’s all!
Now that you know, Conolidine alkaloid is not an ordinary alkaloid. It is, instead, an analgesic alkaloid that is as effective as opioids but not harmful like opioids. So, stop using opioids and start the non-opioid analgesic made from the Crepe jasmine plant.
