EVANSTON, Ill. -- Targeted drug-delivery systems hold significant promise for treating cancer effectively by sparing healthy surrounding tissues.
A Northwestern University research team has developed a new way to determine whether or not single drug-delivery nanoparticles will successfully hit their intended targets -- by simply analyzing each nanoparticle's distinct movements in real time.
By studying drug-loaded gold nanostars on cancer cell membranes, the researchers found that nanostars designed to target cancer biomarkers transited over larger areas and rotated much faster than their non-targeting counterparts.
"Moving forward, this information can be used to compare how different nanoparticle characteristics -- such as particle size, shape and surface chemistry -- can improve the design of nanoparticles as targeting, drug-delivery agents," said Northwestern's Teri Odom, who led the study.
The study published today (Aug. 9) in the journal ACS Nano.
Odom is the Charles E. and Emma H. Morrison Professor of Chemistry in Northwestern's Weinberg College of Arts and Sciences.
COLUMBUS, Ohio -- Electromagnetic fields might help prevent some breast cancers from spreading to other parts of the body, new research has found.
The study showed that low intensity electromagnetic fields hindered the mobility of specific breast cancer cells by preventing the formation of long, thin extensions at the edge of a migrating cancer cell.
The research was done on cells in a lab, and the concept hasn't yet been tested in animals or humans.
"A cancer cell has a tendency to do the most destructive thing imaginable," said Jonathan Song, lead author of the study.
"One very destructive thing these cells do is migrate to distant areas of the body," he said.
"And what we learned here is that it seems by treating them with a certain class of electric field we are altering their potential to spread somehow."
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