Photodynamic therapy (PDT) has emerged as a promising treatment option for various cancers and non-cancerous conditions. In this article, we will explore what PDT is, how it works, the conditions it can treat and its advantages over other therapies.
What is Photodynamic Therapy?
Photodynamic therapy (PDT) is a minimally invasive treatment that uses a photosensitizing chemical agent and a particular type of non-thermal laser light to destroy diseased cells. The therapy involves injecting or applying a photosensitizing agent which is absorbed by the targeted cells. These agents, called photosensitizers, are non-toxic to healthy cells but become activated by specific wavelengths of light. After allowing time for the photosensitizer to build up more in the diseased cells, the area is treated with laser light of a specific wavelength that matches the absorption spectrum of the photosensitizer. This activates the photosensitizer which then produces reactive oxygen species, such as singlet oxygen, that destroys the cells. Nearby healthy cells are undamaged as they do not absorb or retain significant amounts of the photosensitizing agent.
Conditions Treated with PDT
PDT has proven effective for a variety of cancers as well as certain non-malignant conditions. Some of the major conditions where PDT is used include:
- Skin cancer: PDT is an effective treatment for actinic keratosis, Bowen’s disease and certain types of non-melanoma skin cancers like basal cell carcinoma. The photosensitizers used include methyl aminolevulinate and 5-aminolevulinic acid.
- Lung cancer: Early stage non-small cell lung cancer can be treated with PDT using porfimer sodium or verteporfin as photosensitizers.
- Esophageal cancer: PDT helps treat pre-cancerous conditions and some early esophageal cancers, especially when combined with ablation or resection. Porfimer sodium is commonly used.
Advantages of Photodynamic Therapy
Compared to other treatment modalities, PDT offers several unique advantages:
Precision and minimal invasiveness: Only the area directly exposed to laser light is affected, allowing treatment of very localized disease safely. Surrounding healthy tissues are undamaged. This precision minimizes complications.
Higher cure rates for early cancers: For very early stage cancers, PDT can achieve cure rates comparable or superior to surgery with much less damage to healthy tissues.
Well tolerated with few side effects: As there is no extensive surgery or high-intensity treatments like chemotherapy, PDT has an excellent safety profile with minimal discomfort, scarring or adverse effects.
How Photodynamic Therapy Works
The key events in photodynamic therapy can be summarized as follows:
1. Administration of a photosensitizing drug: These are non-toxic chemical dyes or porphyrins administered intravenously, orally or as a topical cream depending on the condition.
2. Accumulation in targeted tissues: The photosensitizer accumulates preferentially in malignant or diseased tissues over a period of 24-96 hours.
3. Light activation: A non-thermal laser or intense light source of a specific wavelength is used to illuminate the target tissue after the photosensitizer has had time to accumulate.
4. Generation of reactive oxygen: Light activation causes the photosensitizer to produce reactive oxygen species like singlet oxygen that can damage important cell components like membranes, mitochondria and DNA.
The Future of Photodynamic Therapy
As research in photosensitizers and light delivery methods progresses, the scope of PDT is expanding to new areas. Combinations with immunotherapy hold promise to further boost outcomes. In the near future, PDT may find wider applications in treating many solid cancers, reducing disease recurrence and improving survival. With its minimal invasiveness and excellent cure rates for early disease, PDT is certainly set to play a greater role in multimodal cancer management protocols. Its applications are also being explored for other conditions like chronic wounds, acne, wrinkles and age-related macular degeneration.
In summary, photodynamic therapy is a highly targeted and well-tolerated treatment approach that employs the principles of photochemistry to induce selective tumor cell death and tissue damage. With continued advances, it promises to effectively treat an increasing number of cancers and other diseases in a minimally invasive manner.
According to the report, the global photodynamic therapy market was valued at ~US$ 3 Bn in 2018, and is projected to expand at a CAGR of ~17% from 2019 to 2027.Read Report Overview - https://www.transparencymarketresearch.com/photodynamic-therapy-market.html Global Photodynamic Therapy Market: Key InsightsPhotodynamic therapy is a part of treatment that uses drugs and devices for the treatment of different chronic diseases such as cancer and malignant musculoskeletal tumors.Increase in the prevalence as well as incidence of cancer and skin diseases, growth in the number of surgeries, and approval of new biologics are major factors anticipated to drive the global photodynamic therapy market during the forecast period.According to the National Cancer Institute of the U.S., around 1,735,350 new cancer cases were diagnosed in the U.S. in 2018.
The USPTO granted a patent titled as ‘Metal-based Thiophene Photodynamic Compounds and their Use.’The photodynamic therapy market in Asia Pacific is expected to expand at a high CAGR of ~18%from 2019 to 2027, due to surge in the number of patients with psoriasis and acne, and rise in the demand for innovative cosmetic therapies in India, China, and South Korea.Request Brochure – https://www.transparencymarketresearch.com/sample/sample.php?flag=B_id=69615Rise in Prevalence of Skin Diseases to Drive Global Photodynamic Therapy MarketRise in the prevalence of skin diseases, worldwide, is projected to drive the global photodynamic therapy market during the forecast period.Acne is considered one of the most common skin conditions in the U.S., which affects over 50 millionpeople in the country every year.
Its prevalence is known to be higher among women, affecting over 15% of the total population of adult women.Psoriasis is known to affect over5 million people in the U.S. every year, with a higher rate of prevalence among people aged between 45 and 64 years.
This significant rise in the prevalence of skin diseases and the economic burden of these diseases generate high demand for photodynamic therapy, which is a cost-effective option.Request COVID Analysis on Photodynamic Therapy Market – https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19_id=69615Photosensitizers Drugs Dominate Global Photodynamic Therapy MarketIncrease in the number of clinical trials for the development of new photosensitizers, rise in the number of market players strengthening their research and development activities, and increase in expenditure on new drug development are various factors expected to drive the drugs segment during the forecast period.In September 2018, Health Canada approved the clinical trial application (CTA) filed by Theralase Technologies Inc., allowing clinical study evaluation of Theralase’s lead anti-cancer drug, i.e.
TLD-1433.Cancer the Most Prominent Application in Photodynamic Therapy MarketIn terms of application, the global photodynamic therapy market has been segmented into cancer, actinic keratosis (AK), psoriasis, acne, and others.
In October 2019, Theralase Technologies Inc. was granted a patent in Europe for its anti-cancer light-activated photodynamic compounds (PDCs).Request Customization on Photodynamic Therapy Market Report –https://www.transparencymarketresearch.com/sample/sample.php?flag=CR_id=69615Hospitals a Promising End User of Global Photodynamic Therapy MarketIn terms of end user, the global photodynamic therapy market has been categorized into hospitals, cosmetics & dermatology clinics, cancer treatment centers, and others.The cosmetics & dermatology clinics segment is likely to gain significant market share by 2027.
It includes the size, share, growth, trends, key players, segments and regional analysis in detail during the study year 2020-2027.The research report also covers the comprehensive profiles of the key players in the market and an in-depth view of the competitive landscape worldwide.
The major players in the laser fiber in medical applications market include Amonics Ltd., Apollo Instruments Inc., Coherent Inc., IPG Photonics Corporation, Jenoptik Laser GmbH, CY Laser SRL, NKT Photonics A/S, Quantel Group, TRUMPF, and Toptica Photonics AG.
This section consists of a holistic view of the competitive landscape that includes various strategic developments such as key mergers & acquisitions, future capacities, partnerships, financial overviews, collaborations, new product developments, new product launches, and other developments.Get more information on "Global Laser Fiber in Medical Applications Market Research Report" by requesting FREE Sample Copy at https://www.valuemarketresearch.com/contact/laser-fiber-in-medical-applications-market/download-sampleMarket DynamicsFiber laser has become a prefered choice for many medical applications, primarily due to the physical feature of fiber waveguide structure and numerous research and improvements.
Photodynamic therapy (PDT) by laser systems is a minimally invasive strategy for the removal of tumors.
The mounting burden of cancer worldwide and rapid progress in various researches is predicted to create new market opportunities.
However, insufficient acceptance of the laser fiber and lack of skilled surgeons hamper demand for laser fiber in medical applications.The research report covers Porter’s Five Forces Model, Market Attractiveness Analysis, and Value Chain analysis.
